Homologous type ii collagen—induced arthritis in rats
نویسندگان
چکیده
منابع مشابه
Type Ii Collagen - Induced Arthritis in Mice
The induction of immunological reactivity to type II collagen, a major component of cartilage, has recently been used to establish an experimental model of arthritis in the rat (1). Trentham and colleagues (1) have shown that the intradermal injection of collagen in Freund's complete or incomplete adjuvant elicits an arthritogenic reaction, specifically with native type II collagen. Arthritis o...
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Spirulina platensis, a filamentous, multicellular microalga, is grown in certain countries as food for human and animal consumption. It is also used to derive additives in pharmaceuticals and foods. The present study was undertaken to examine the immunomodulatory effect of S. platensis in collagen induced arthritis (CIA) in rats. From the zero day of induction of arthritis, S. platensis (200 an...
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We have recently described a new animal model of arthritis induced by intradermal injection of a distinct type of collagen found in cartilage (type II collagen). Since immunologic sensitivity to collagen could play a role in the pathogenesis of this type II collagen-induced arthritis in rats, the ability of purified types of native collagens to induce cellular and humoral responses was quantifi...
متن کاملPassive transfer by cells of type II collagen-induced arthritis in rats.
To investigate the role of immunologic hypersensitivity to collagen in the causation of type II collagen-induced arthritis in rats, passive transfer experiments were performed. Wistar/Lewis rats used in these experiments were demonstrated to be histocompatible by prolonged skin graft survival and mixed lymphocyte cultures. Popliteal lymph node weight assays excluded a potential for graft-vs.-ho...
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The effects of steroidal and non-steroidal anti-inflammatory drugs on the established lesion of type II collagen induced arthritis in rats were evaluated by measuring the hind paw oedema and anti-type II collagen antibody titre. Dexamethasone, a steroidal anti-inflammatory drug, reduced the anti-type II collagen antibody titre and markedly suppressed the established lesion of type II collagen i...
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ژورنال
عنوان ژورنال: Arthritis & Rheumatism
سال: 1990
ISSN: 0004-3591,1529-0131
DOI: 10.1002/art.1780330512